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Penn scientists are highlighted in a Philadelphia Inquirer article about their discovery of a genetic stutter that may influence the risk of developing ALS. Aaron Gitler, PhD, assistant professor of Cell and Developmental Biology; John Trojanowski, MD, PhD, director of the Institute of Aging; Nancy Bonini, PhD, professor of Biology; and Virginia Lee, PhD, co-director of the Center for Neurodegenerative Disease Research, all co-authors on the Nature paper describing the work, were mentioned in the article. The finding links several ALS-related clues, including a 2006 discovery also made by Penn researchers that people with ALS build up abnormal deposits of a protein called TDP-43 in their brains.

Penn scientists are highlighted in a Philadelphia Inquirer article about their discovery of a genetic stutter that may influence the risk of developing ALS. Aaron Gitler, PhD, assistant professor of Cell and Developmental Biology; John Trojanowski, MD, PhD, director of the Institute of Aging; Nancy Bonini, PhD, professor of Biology; and Virginia Lee, PhD, co-director of the Center for Neurodegenerative Disease Research, all co-authors on the Nature paper describing the work, were mentioned in the article. The finding links several ALS-related clues, including a 2006 discovery also made by Penn researchers that people with ALS build up abnormal deposits of a protein called TDP-43 in their brains.

The August issue of The Scientist profiles Aaron Gitler, PhD, assistant professor of Cell and Developmental Biology and his work with yeast and neurodegenerative disease proteins. Gitler is as confident as ever that these simple model organisms can provide powerful insights into human disease, but he is also moving his research into human tissues. It is this part of his research that Gitler now finds particularly rewarding. “Now we’re really touching on human disease,” he says.

The August issue of The Scientist profiles Aaron Gitler, PhD, assistant professor of Cell and Developmental Biology and his work with yeast and neurodegenerative disease proteins. Gitler is as confident as ever that these simple model organisms can provide powerful insights into human disease, but he is also moving his research into human tissues. It is this part of his research that Gitler now finds particularly rewarding. “Now we’re really touching on human disease,” he says.

A examination in Science, conducted by John Weisel, PhD, professor of Cubicle and Developmental Biology, suggests the key to a blood clots’ pliability is the way each molecule unfolds when tugged, exposing hidden inner parts of the fibrin string that then actively put unstintingly. "That's how the with few exceptions clot tome decreases about ten-fold with three-fold stretching," says Weisel in a NPR Strength Blog. It's this molecular unfolding that allows clots to blow up so far <<>>